Sign up for our virtual series covering the Ensembl genome browser and accessing Ensembl data via its REST API. Both workshops will be held from Tuesday to Thursday, with the browser course running from 10th to 12th October and the REST API course from 17th to 19th July (09:00 – 12:00 BST). Read on for more information and how to register.
Continue readingTag: VEP
Cool stuff Ensembl VEP can do – enhanced Structural Variant annotation
In Ensembl release 110, we have extended the analysis options available for structural variants (SV) in Ensembl VEP including more detailed molecular consequence predictions, more efficient integration of information from reference SV sets, support for breakend variant annotation and the integration of CADD-SV scores.
Continue readingFree Ensembl Browser and REST API virtual workshops in July
Sign up for our virtual series covering the Ensembl genome browser and accessing Ensembl data via its REST API. Both workshops will be held from Tuesday to Thursday, with the browser course running from 11th to 13th July and the REST API course from 18th to 20th July (14:00 – 17:00 BST). Read on for more information and how to register.
Continue readingCool stuff Ensembl VEP can do: Using Gene Ontology annotations to understand gene function
Ensembl VEP maps your variants to genes but what do those genes do?
The Gene Ontology (GO) annotates genes with molecular function, the cellular location in which the gene product functions and the biological process in which the gene product is involved. In addition to phenotype association information, which is only available for a few genes, we now show GO annotations to help guide variant prioritisation by providing an indication of the functionality a variant may affect.
Continue readingWhat’s coming in Ensembl 110 / Ensembl Genomes 57?
Ensembl 110 and Ensembl Genomes 57 are expected to be released in May 2023 July 2023. Find out what’s coming in the new release, although we cannot guarantee everything listed here will make it into the final release.
PolyPhen-2 and SIFT scores are changing in release 109
We are updating SIFT and PolyPhen-2 predictions of missense variant deleteriousness in the Ensembl browser and Ensembl VEP with the new release 109. We have recalculated all scores using newer software versions, updating PolyPhen-2 from 2.2.2 to 2.2.3 and SIFT from version 5.2.2 to 6.2.1. When we update software and reference data versions, we expect to see changes in some predictions. This is a guide as to what you can expect.
Continue readingWhat’s coming in Ensembl release 109 / Ensembl Genomes 56?
Ensembl 109 and Ensembl Genomes 56 are expected in February 2023. Check out what we’re up to, although we can’t guarantee everything listed here will make it into the final release.
Continue readingFree Ensembl Browser and REST API virtual workshops in November
Virtual series covering the genome browser and the REST API. Both workshops will be held between Tuesday – Thursday, with the Browser on 15th – 17th November and the REST API on 22nd – 24th November 2022 (9am-12pm GMT). Read on for more information and registration instructions.
Continue readingCool stuff Ensembl VEP can do: display variants on AlphaFold-predicted 3D protein structures
The AlphaFold AI system developed by DeepMind predicts a protein’s 3D structure from its amino acid sequence. You can now view variant locations on AlphaFold predicted structures in the Ensembl VEP web tool.
Continue readingCool stuff Ensembl VEP can do – provide evidence of protein interaction impact
Ensembl VEP integrates information from many different resources to help you interpret the functional impact of your variants. It now reports when variants fall in sites with evidence of impact on protein interactions, as described in the IntAct database.
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