In Ensembl release 109, we introduce a new display that integrates experimentally verified interactions between genes, proteins, mRNA or other small molecules onto our gene pages. This adds an additional layer of data that enables deeper analysis into the ways species interact in a variety of contexts. So far, we have imported curated interactions from PHI-base, HPIDB, and PlasticDB for which we could find exact protein matches in Ensembl.

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We are pleased to announce the release of Ensembl 109, and the corresponding release of Ensembl Genomes 56. The release brings updates to donkey and horse assembly and lots of new Plants and Metazoa genomes. We have updated PolyPhen-2 and SIFT scores on VEP and Ensembl browser. And we have a shiny new resource that shows molecular interactions involving genes in Ensembl; ranging from pathogen-host interactions to symbiotic relationships across microbes and other Ensembl species.

New and exciting genome assemblies and annotations for many new species are being continuously added to the Ensembl Rapid Release genome browser.

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Firstly, a very happy new year from us at Ensembl. We spent last year adapting to the new and exciting challenges with the reopening of the Wellcome Genome campus. Like other research institutes around the world, EMBL EBI has risen to the occasion, acting swiftly to safeguard staff and students and embracing the new ways of hybrid working in creative and bold ways. 

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We are updating SIFT and PolyPhen-2 predictions of missense variant deleteriousness in the Ensembl browser and Ensembl VEP with the new release 109. We have recalculated all scores using newer software versions, updating PolyPhen-2 from 2.2.2 to 2.2.3 and SIFT from version 5.2.2 to 6.2.1. When we update software and reference data versions, we expect to see changes in some predictions. This is a guide as to what you can expect.

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We are pleased to announce that Ensembl Rapid Release 40 with 94 new genomes is now live! With Rapid Release 40, we also introduce the first of many invertebrate-themed Ensembl Rapid Releases. The inaugural theme has an emphasis on scientific advancements in global food security. We have added 21 agriculturally significant insect species, which include organisms viewed as priorities in the pursuit of boosting fundamental biological understanding and insights into biological control mechanisms, both indispensable to increase global food production and availability.

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