Disruptions are now resolved and Ensembl services are back to normal.

We have temporarily disabled Ensembl Tools, for example VEP and BLAST/BLAT on our vertebrate live websites (www, US East, US West, Asia and GRCh37) whilst we investigate a problem with the underlying infrastructure in our Harlow data center. Some of our archive resources are also currently unavailable. We are sorry for the trouble this may cause and we hope to restore them as soon as we can. Other resources such as our FTP site and public MySQL servers are unaffected.

Ensembl is rapidly working towards annotating large collections of genomes based on the nodes of the Earth BioGenome Project. Our aim is to characterise the genome of new species to reinvigorate our understanding of biological diversity, strengthen conservation efforts, and benefit human welfare. Read more to find out how Ensembl will contribute to tackle the climate change challenges that face the world today.

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The quickest and most flexible way to run Ensembl VEP on large scale variant sets is to install and run it locally. Depending on the use case, the underlying architecture, and the available permissions, installing VEP prerequisites is prone to complications. To aid with this, we have made the VEP available with containers.

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Have you missed out on the open Ensembl workshops in May? We’ve got another round of our recurring virtual series covering the genome browser and the REST API. Both workshops will be held between Tuesday – Thursday, with the Browser on 8th-10th June and the REST API on 15th-17th June 2021 (9am-12pm BST). Read on for more information and registration instructions.

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Ensembl 104 and Ensembl Genomes 51 are out! This release features updates to human and mouse genes, GRCh37 variation and regulation, new assemblies and variation for vertebrates, new plant species and a large update of the available metazoa data. We also said bye-bye to clone-based gene names and welcomed the new Ensembl Canonical transcripts.

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To better understand how your variants might be linked to disease, you can add information from DisGeNET to your VEP analysis. DisGeNET integrates data from expert curated repositories, GWAS catalogues, animal models and the scientific literature, to provide disease associations with genes and variants.

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Update: registration is now closed as all of the available places on the virtual Ensembl browser and REST API workshops have been filled. If you would like to be added to the waiting list, please e-mail the Ensembl Helpdesk.

We’ve got another round of the free virtual Ensembl workshops covering the genome browser and the REST API. The Browser workshop will be held between Tuesday 18th May – Thursday 20th May 2021 (7pm-10pm BST) and the REST API workshop will be held between Tuesday 25th May – Thursday 27th May 2021 (7:30pm-10pm BST). Read on for more information and registration instructions.

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Upcoming Ensembl release 104 will bring an update to the Ensembl Canonical transcripts. The new Ensembl Canonical definition will prioritise well-supported biologically representative, highly expressed and highly conserved transcripts. MANE Select will be used as the canonical transcript for human protein coding genes where available.

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