Ensembl 74 has been released!

What’s new in e!74?

  • Updated human GENCODE release 19 and mouse GENCODE release M2 gene sets including manual annotation from Havana
  • New assembly patches for human (GRCh37.p13) and mouse (GRCm38.p2)
  • dbSNP Build 138 data for human, mouse and cow
  • New secondary structure models for ncRNAs
  • New matrix configuration for RNASeq models for humansheep and opossum
  • Updated human phenotype data
  • COSMIC version 67 and update of COSMIC structural variants
  • Variation data for sheep from dbSNP build 128 as well as imported sheep genotyping chips
  • Added mouse phenotype data from IMPC (International Mouse Phenotyping Consortium)
  • New species: sheep, cave fish and spotted gar
  • Updated armadillo assembly to Dasnov3.0. Tissue-specific gene models with indexed BAM files are also provided.

New matrix configuration for RNASeq models

Human RNASeq matrixTo make management of large number of tracks easier, configuration for RNASeq models for human, sheep and opossum now appears as a matrix.

New page displaying ncRNA secondary structure

Secondary structure of RNAs The secondary structure of ncRNAs is now displayed on the Gene Summary page. Clicking on the “enlarge” link below the image will take you to a new page showing more detail of the structure, including base pair mutations and sequence degeneration.

New species

We are happy to announce annotation for three new species in this release.

SheepThe sheep (Ovis aries) assembly, Oar_v3.1 (GCF_000298735.1), was produced by the International Sheep Genomics Consortium (ISGC). Sheep is an important livestock animal reared for meat, fleece and milk. We have generated BAM files and RNASeq-based gene models for  91 samples, including a wide range of tissues between a trio (ram, ewe and lamb), 7 tissue types from the reference sheep and different tissue samples from different breeds.

Cave fish

The blind cave fish (Astyanax mexicanus) assembly, AstMex102 (GCA_000372685.1), was produced by the Washington University. This species is used as a model organism in the study of retinal degeneration. We have generated a BAM file and RNASeq-based gene models for cave fish.

Spotted garThe spotted gar (Lepisosteus oculatus) assembly, LepOcu1 (GCA_000242695.1), was produced by the Broad Institute of MIT and Harvard. Spotted gar is biologically similar to other fish, yet its genome is surprisingly similar to human. It is therefore used as a model for understanding human development, and represents a connection to medical models in the teleost clade. We have generated BAM files and RNASeq-based gene models for 10 different tissues.

A complete list of the changes can be found on the Ensembl website.