The lastest Ensembl update (e!71) has just gone live!

What’s new in e!71?

• SIFT scores for all possible changes to the proteome in human, mouse, zebrafish, pig, cow, chicken, rat and dog. Find them in the variation table, through the VEP or using the variation API.
• New views and web features
  • New “clinically associated” summary track on Region in Detail for human variation
  • Expression view
  • Transcript comparison view
  • Scrollable overview on region in detail
• Import of COSMIC version 63 and update of COSMIC structural variants
• Updated gene sets
  • Human and zebrafish, with manual annotation from HAVANA
  • Anole lizard, including RNAseq data
• Variation data available in VCF format on the FTP site
• Phenotype data for some farm animals
• New assemblies
  • Chicken (Galgal4), including RNAseq
  • C. elegans (WBcel235)

New views and web features

We have added a new “clinically associated” summary track for Human showing ClinVar variants.

We have added a new expression view to the set of gene-based displays, listing the available RNASeq data for a given species, with links through to Region in Detail that turn on a set of RNAseq tracks for a given tissue.

A new transcript comparison view allows comparison of transcript sequences for a gene.

A scrollable overview panel (supported by most updated browsers) is now available on the Region in detail view.  If you do not have a compatible browser you will see the static Region in detail view, and there is an option available to switch between scrollable and static images for supported browsers.

The RNASeq data supporting the introns of RNASeq genes is now shown on the Supporting evidence panels for those transcripts. The display distinguishes between alignments that support canonical and ones that support non-canonical splice sites.

New Assemblies

We are happy to introduce two assembly updates for this release.

The chicken (Gallus gallus) genome, Galgal4, was produced by the International Chicken Genome Sequencing Consortium. In addition to being important agriculturally, the chicken is an important model organism for biomedical research, development, and ageing. The chicken is also one of the primary models for embryology and development, the study of viruses, and cancer.

The WBcel235 assembly of C. elegans (Caenorhabditis elegans) has been imported from the WS235 release of WormBase. C. elegans provides a model for complex organ systems, as well as developmental biology and genetics.