Ensembl is currently undergoing a major transformation to provide faster, more flexible, and more scalable access to genome data. As outlined in our Ensembl 2026 publication, work on the new platform is well underway and can already be explored at beta.ensembl.org. In this blog, we are sharing important information about upcoming changes to Ensembl data access, including timelines, new services, and what you need to do to prepare.

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We have made a number of changes in Ensembl Compara Perl API and REST API endpoints. These changes allow Ensembl to handle non-unique member stable IDs when retrieving comparative genomics data via the APIs. These changes will come into effect in Ensembl release 110 and all old endpoints will be retired in release 112. Please continue reading if you regularly retrieve comparative genomics data via the Ensembl APIs.

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