We are pleased to announce the release of Ensembl 114, and the corresponding release of Ensembl Genomes 61. This release brings an updated MANE set (v1.4) for the human GRCh38 assembly. We have updated existing data sets and added lots of exciting new genomes across the different Ensembl sites including rodents, livestock, plant, microbial and metazoa species. Variation data has been updated to EVA release 6 and is available for 39 species.

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Ensembl VEP calculates the location and likely impact of variant alleles on genes, producing extensive annotations, but there are now a huge number of human transcripts to consider. The new GENCODE Primary transcript set streamlines the variant annotation process, saving time in both analysis and results filtering/ interpretation.

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Sign up for our virtual series covering the Ensembl genome browser and accessing Ensembl data via its REST API. Both workshops will be held from Tuesday to Thursday, with the browser course running from 7th to 9th May and REST API from 14th to 16th May 2024 (14:00-17:00 BST). Read on for more information and how to register.

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We are experiencing issues with the Ensembl search system due to unforeseen errors. The search function is currently unavailable and this may affect other functions such as the loading of variants on genomic sequences. To search for entries in Ensembl, you can do one of the following:

  1. Use the EMBL-EBI website: go to https://www.ebi.ac.uk/ebisearch and enter your search terms into the text box. E.g. if you want to search for human BRCA2 in Ensembl, enter Ensembl human BRCA2 into the search text box.
  2. Use Google: to search for entries in Ensembl via Google, go to www.google.com and enter site:https://www.ensembl.org [search terms]. E.g. if you want to search for human BRCA2, enter site:https://www.ensembl.org human BRCA2 into Google.

We are working to fix this issue as quickly as possible, although a timeline is still unclear for the work to be completed. Services will be resumed as soon as the issue has been resolved. If you have any questions, please contact us on the Ensembl Helpdesk.

Sign up for our virtual series covering the Ensembl genome browser and accessing Ensembl data via its REST API. Both workshops will be held from Tuesday to Thursday, with the browser course running from 10th to 12th October and the REST API course from 17th to 19th July (09:00 – 12:00 BST). Read on for more information and how to register.

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