by ·Comments Off on Expanded transcript set available in the latest human GRCh38 partial release on the new Ensembl site

In the current Ensembl release (Ensembl 115), the GRCh38 human Ensembl/GENCODE reference annotation was updated to include approximately 121,000 new protein-coding transcripts. This expanded set is based on long-read RNA-seq data processed by the manually supervised automated pipeline TAGENE, which is presented as the source in both browser and files.

The latest partial release for GRCh38 on the new Ensembl (partial release 2026-01-26) includes this new geneset. Some genes and genomic features in this set have several hundred transcripts, such as ZBTB20 (ENSG00000181722) which has 360 transcripts.

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by ·Comments Off on What’s coming in Ensembl release 116 / Ensembl Genomes 63?

Ensembl 116 and Ensembl Genomes 63 are expected in April 2026. Check out what we’re up to, although we can’t guarantee everything listed here will make it into the release. 

Special Notice

Ensembl 116 and Ensembl Genomes 63 will be the final releases on the current Ensembl site and platforms.

From the summer of 2026, all new data will only be available through the new Ensembl site. The site, ensembl.org, will redirect to the site currently hosted on beta.ensembl.org. 

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by ·Comments Off on Large plant protein clusters accessible via gene families view

In Ensembl release 116 (Ensembl Genomes 63), two large protein clusters in Plants have incomplete or missing homology data due to production constraints. To address this, we set about making these clusters accessible via the gene families view. Please read on if you’d like to know more about these clusters, both associated with the Panther subfamily ‘PTHR11439_SF127’.

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by ·Comments Off on Service notice – server issues affecting the Ensembl mirror sites

We are working on server issues affecting the Ensembl mirror sites. A workaround is to use the Ensembl main site via the following link – https://ensembl.org?redirect=no or a recent archive such as https://may2025.archive.ensembl.org/. You can also try the new Ensembl site at https://beta.ensembl.org and let us know about the features you would like to see there.

by ·Comments Off on Updates to programmatic access to Ensembl and transitioning to the new Ensembl Platform

Ensembl is currently undergoing a major transformation to provide faster, more flexible, and more scalable access to genome data. As outlined in our Ensembl 2026 publication, work on the new platform is well underway and can already be explored at beta.ensembl.org. In this blog, we are sharing important information about upcoming changes to Ensembl data access, including timelines, new services, and what you need to do to prepare.

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by ·Comments Off on Cool stuff Ensembl VEP can do: annotate structural variants with gnomAD allele frequencies and ClinVar clinical significance 

To support the filtering and interpretation of structural variants (SVs), the Ensembl VEP web interface has been extended in release 115 to annotate them with allele frequencies from gnomAD and clinical significance from ClinVar.

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by ·Comments Off on Cool stuff Ensembl VEP can do: reporting functional assay results from MaveDB

Ensembl VEP makes it easy to annotate your variants with the reference data essential to variant filtering and interpretation. This includes the results of multiplex assays of variant effect (MAVEs) which report on observed cellular phenotypes across nearly all possible variants in specific targeted regulatory or coding regions.

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by ·Comments Off on Getting to know us Jorge from Ensembl Outreach

Welcome to our Getting to know us (a.k.a. Teamsembl) blog series, where we talk to Ensembl colleagues and ask them a series of questions about their role in the project. For this month, we chatted with Jorge Batista da Rocha, who is the project leader of the Ensembl Outreach team. Join us as we learn more about Jorge’s role at Ensembl.

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by ·Comments Off on Ensembl 115 has been released!

We are pleased to announce the release of Ensembl 115, and the corresponding release of Ensembl Genomes 62. In this release – around 121,000 new protein-coding transcripts have been added to the GRCh38 human reference gene set. Two new breeds of cattle are now available (UOA_Tuli_1 and UOA_Wagyu_1) and the sheep reference has been updated to ARS-UI_Ramb_v3.0. Seven new plant species have been added: four oats, two garden peas, and one lablab bean. We have also added two new export modes for Newick trees which help to avoid stable ID clashes.

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