In the current Ensembl release (Ensembl 115), the GRCh38 human Ensembl/GENCODE reference annotation was updated to include approximately 121,000 new protein-coding transcripts. This expanded set is based on long-read RNA-seq data processed by the manually supervised automated pipeline TAGENE, which is presented as the source in both browser and files.

The latest partial release for GRCh38 on the new Ensembl (partial release 2026-01-26) includes this new geneset. Some genes and genomic features in this set have several hundred transcripts, such as ZBTB20 (ENSG00000181722) which has 360 transcripts.

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Ensembl 116 and Ensembl Genomes 63 are expected in April 2026. Check out what we’re up to, although we can’t guarantee everything listed here will make it into the release. 

Special Notice

Ensembl 116 and Ensembl Genomes 63 will be the final releases on the current Ensembl site and platforms.

From the summer of 2026, all new data will only be available through the new Ensembl site. The site, ensembl.org, will redirect to the site currently hosted on beta.ensembl.org

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We are working on server issues affecting the Ensembl mirror sites. A workaround is to use the Ensembl main site via the following link – https://ensembl.org?redirect=no or a recent archive such as https://may2025.archive.ensembl.org/. You can also try the new Ensembl site at https://beta.ensembl.org and let us know about the features you would like to see there.

We are pleased to announce the release of Ensembl 115, and the corresponding release of Ensembl Genomes 62. In this release – around 121,000 new protein-coding transcripts have been added to the GRCh38 human reference gene set. Two new breeds of cattle are now available (UOA_Tuli_1 and UOA_Wagyu_1) and the sheep reference has been updated to ARS-UI_Ramb_v3.0. Seven new plant species have been added: four oats, two garden peas, and one lablab bean. We have also added two new export modes for Newick trees which help to avoid stable ID clashes.

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Please note that due to planned maintenance, Ensembl Tools will be unavailable from Tuesday, September 9 2025, at 08:30 AM BST until Wednesday, September 10 2025, at 08:30 AM BST. 

Jobs submitted during the maintenance window will be queued and processed once maintenance is complete.

We apologise for the inconvenience. Services will be resumed as soon as the work has been completed. If you have any questions about the planned maintenance work, please contact us via the Ensembl Helpdesk.