In its latest release, Ensembl has completely reviewed its reporting of potential Transcription Factor (TF) binding sites. TF proteins are key players of gene expression regulation that bind to specific DNA regions characterised by approximate sequence patterns, or transcription factor binding motifs (TFBM). These motifs are generally represented as a Position Specific Frequency Matrix, or Binding Matrix. Ensembl scans genomes for occurrences of these motifs, reporting Motif Features at each possible location.
Category: Release announcements
Release announcements for Ensembl and Ensembl Genomes
We’ve just released Ensembl Genomes 94, which includes genomes for Emmer wheat and over 200 new fungi, updated gene trees and host-pathogen interactions from PHI-base.
The latest version of Ensembl, release 94, is out and have we got some treats for you. As well as GENCODE updates for human and mouse, we’ve also got loads of new fish. Plus, we have brand new transcription factor binding motifs, additional predictors of variant pathogenicity and updated gene tree pipelines.
Rating variants for their potential deleteriousness is vital for solving the link between genotypes and phenotypes. There are many different algorithms for predicting how likely it is that a human variant would affect the function of a protein, and in release 94 of Ensembl, we’ll be making more of these available.
We’re planning to release the next Ensembl and Ensembl Genomes in September.
We’ve got some exciting new genomes, including Emmer wheat, lots of fish and fungi. We’ve also got GENCODE updates for human and mouse, and new transcription factor binding motifs.Continue reading
The path to sequencing the wheat genome has been no easy ride, due to its large and highly repetitive genome. This new assembly from the IWGSC bridges many gaps from the initial genome sequencing effort. Read on to find out more about this exciting new genome assembly!
We’ve been tending the Ensembl Plants garden with great care, have cultivated several new species and updated a number of genome assemblies, including a new chromosome-level wheat genome from IWGSC. The protist team have also been busy and are proud to announce an updated assembly for Leishmania major.
Read on to find out more about these exciting new updates and more in this new release of Ensembl Genomes!
Are you feline excited for our new pawsome release?!
Ensembl 93 has been released, bringing with it two new big cat genomes for tiger and leopard, and an update to the domestic cat assembly. If cats aren’t your thing, we also have a huge new dbSNP import for human and a brand new regulatory build and GENCODE update for mouse.
We also have a new hagfish genome, important changes to our VEP REST endpoints, and many more exciting developments so read on to find out more!
As of Ensembl release 93, which is due at the end of the month, the Gene Variant Image view will be retired for human. We have elected to retire this page because we feel that the density of known genetic variation is too great for this view to be informative in its current form.