Regulation FTP resources restructured in Ensembl 87

The Ensembl regulation resources FTP site saw a facelift in release 87. The directory structures have been modified to make it easier to find files- the file names have become more descriptive and we now also provide our data in a greater variety of Continue reading Regulation FTP resources restructured in Ensembl 87

Find predicted CRISPR sites using Ensembl

Find predicted CRISPR sites using Ensembl

The CRISPR/Cas9 system has revolutionised scientific research over the last few years, offering an efficient method of genome editing. CRISPR/Cas9 utilises the cellular machinery used by bacteria to recognise and edit the DNA of invading viruses. It is formed of two key components: Continue reading Find predicted CRISPR sites using Ensembl

Computing Ensembl’s New Regulatory Annotation

Computing Ensembl's New Regulatory Annotation

We described in a previous post Ensembl’s new regulatory annotation of the genome. Now, we will go in greater detail into how we computed it. We started by running ChromHMM over 17 cell types, using publicly available ENCODE and Roadmap Continue reading Computing Ensembl’s New Regulatory Annotation