The Ensembl regulation resources FTP site saw a facelift in release 87. The directory structures have been modified to make it easier to find files- the file names have become more descriptive and we now also provide our data in a greater variety of Continue reading Regulation FTP resources restructured in Ensembl 87
As part of Ensembl 85, we are excited to introduce expression quantitative trait loci (eQTL) data, through our partnership with the Genotype-Tissue Expression (GTEx) project. The GTEx project has the goal of identifying the influence of genetics on tissue-specific gene Continue reading GTEx eQTL data now in Ensembl!
The CRISPR/Cas9 system has revolutionised scientific research over the last few years, offering an efficient method of genome editing. CRISPR/Cas9 utilises the cellular machinery used by bacteria to recognise and edit the DNA of invading viruses. It is formed of two key components: Continue reading Find predicted CRISPR sites using Ensembl
As we announced in our e80 release post, we rolled out a prototype display for cis-regulatory interactions, essentially arches connecting any two elements on the same chromosome. This was mainly designed to display your eQTL or Hi-C with little effort, based on the WashU Continue reading Drawing cis-interactions in Ensembl
After running our brand new Ensembl Regulatory Build on the human GRCh38 and GRCh37 assemblies, we spent some time revamping our current Regulation mart to make it faster, easier to use and pack it with brand new features. A complete re-design of the mart has Continue reading Say hello to the new Regulation mart
Interested in joining our dynamic team near Cambridge, UK, and working at the forefront of genomics? The following positions are open. Find them all on the EBI jobs site. We are looking for a total of three talented computational biologists, Continue reading Ensembl is Hiring!
The brand new Ensembl Regulatory Build on the new GRCh38 human assembly has been released in Ensembl 76. This involved a complete redesign of the build process with a new statistically rigorous logic, a streamlining all the backend processes and a remapping and Continue reading The Ensembl Regulatory Build – the Track Hub
Working as an Outreach Officer for Ensembl means lots of exciting adventures around the world to teach Ensembl to local scientists. Last month I was privileged to be able to travel to South Korea to give an ENCODE workshop with Bob Continue reading A Korean ENCODE adventure
We described in a previous post Ensembl’s new regulatory annotation of the genome. Now, we will go in greater detail into how we computed it. We started by running ChromHMM over 17 cell types, using publicly available ENCODE and Roadmap Continue reading Computing Ensembl’s New Regulatory Annotation
GWAS after GWAS return statistically significant hits that are hard to interpret because they fall outside of coding regions, and this begs for more functional annotation of regulatory regions. We at Ensembl have been providing such an annotation for a Continue reading The New Ensembl Regulatory Annotation