Year of the rat…

Things are moving within the rat community as this month’s Nature Genetics issue shows with a special on rat genetics exploring the latest developments.

Featuring:

  • ENU-induced gene targeting in rats;
  • A ‘white paper’ discussing progress and prospects in rat genetics;
  • A brief overview on rat genome resources online;
  • ENU-induced gene targeting in rats;
  • A contribution on dynamics of CNV in rat and their impact in phenotypes;
  • A survey of genetic variation from The STAR Consortium (over 3 million newly identified SNPs and over 20,000 SNPs genotyped across 167 distinct inbred rat strains);
  • and several papers focusing on the identification of genetic variants associated to rat models of human disease…

The driving force behind these outstanding achievements can be found on a well interliked rat community bridging resources across the Atlantic: RGD and the EURATools Consortium (FP6 contract number LSHG-CT-2005-019015) collaborations are a good example.

EURATools investigators are developing integrated genome tools (Ensembl is one of the partners of this consortium). Integrating high-throughput sequencing and genotyping with informatics; intensive analysis of phenotypes, gene sequence and gene expression in congenic strains to identify genes and regulatory pathways for a wide range of rat disease phenotypes; and establishing optimised protocols for rat gene targeting are the goals of this ambitious EU funded project.

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