We’re looking for a bioinformatician to manage our comparative genomics team, running homology and alignment pipelines on Ensembl genes. We’re looking for PhDs in Molecular Biology or Bioinformatics with experience in comparative genomics, relational databases, HPC clusters and programming. Closes 1st March.
Author: Emily (Outreach)
We’re looking for a manager to lead EMBL-EBI’s contribution to WormBase, a genomics resource for C. elegans. We’re looking for PhDs in Molecular Biology or Bioinformatics, with experience in model organism genomics, using databases for modelling biological data and a programming language. Closes 26th February.
We’re looking for a bioinformatician to work on genomes of non-vertebrate metazoa. We’re looking for Masters in computing or related scientific discipline, with experience in bioinformatics and proficiency in Perl, Python, SQL and Unix. Closes 21st February.
Most of the time when we talk about variant annotation, we talk about the effects of variants on genes, but did you know that the VEP can also tell you how variants affect the genomic features that regulate gene expression, such as promoter and enhancers?
If a variant hits a splice site, you want to know if splicing is going to occur as normal, or if you can expect a different protein isoform. We have a few cool tools with the VEP that will help you to assess that for your own variants.
We’ve heard from a number of you about missing paralogues in release 94. We have lost some paralogy relationships and we’re looking to restore them in future. We’re sorry for any problems this caused.
If you work with Zymoseptoria tritici genes, we’re looking for your help. We need people to get involved with community annotation of genes.
In its latest release, Ensembl has completely reviewed its reporting of potential Transcription Factor (TF) binding sites. TF proteins are key players of gene expression regulation that bind to specific DNA regions characterised by approximate sequence patterns, or transcription factor binding motifs (TFBM). These motifs are generally represented as a Position Specific Frequency Matrix, or Binding Matrix. Ensembl scans genomes for occurrences of these motifs, reporting Motif Features at each possible location.
We’ve just released Ensembl Genomes 94, which includes genomes for Emmer wheat and over 200 new fungi, updated gene trees and host-pathogen interactions from PHI-base.