We’re looking for a web development manager to work on the Ensembl back-end. We’re looking for masters or PhDs in biology, bioinformatics, software engineering with experience developing web applications. Closes 14th August.
Author: Emily (Outreach)
We’re looking for a developer to work on annotating epigenomic elements and regulatory features on the genome. We’re looking for PhDs or MScs in molecular biology, bioinformatics or computer science, with experience in software development, genomics, object oriented programming, Git and SQL. Closes 13th August
Interpreting a single variant can be a lot more involved than just finding out its consequence. Sometimes to understand a variant, you need to know exactly where it falls, which exon, which amino acid, sometimes even which base in the codon. The VEP gives you all of this by default.
Work continues on our exciting new website, which is available as a pre-alpha release. We’ve been consulting with some of you in various ways, such as interviews and meetings, because we want to make sure that the new Ensembl serves your needs. We’re now asking for your help with a short survey, which will just take a couple of minutes to fill in. Plus, you can enter into a draw to win an EMBL-EBI t-shirt.
If you’re really delving into the role of a particular genetic variant, you might want to know about that base position in other species. VEP can get you ancestral alleles in human and conservation scores in many species for a variant position allowing you to assess if a position is evolutionarily important, or if an allele matches our primate ancestors.
If you’re trying to work out which variants are associated with a phenotype or disease, a major thing you might want to know is if someone else has already spotted it. And if not the variant, maybe the gene that it hits. You can get that through the VEP.
The RefSeq column on our gene pages has changed.
We’re moving towards a more unified gene-set with RefSeq, with biologically important transcripts being highlighted as MANE. This means displays you’re used to seeing will be updated to reflect these changes, and this may affect the way you have been working with Ensembl.
We’re fortunate to be part of the EMBL European Bioinformatics Institute (EBI), which puts us alongside stellar bioinformaticians and resources in every discipline. From this, great collaborations can grow. We’ve already worked with our colleagues at Gene Expression Atlas and Reactome to embed widgets in Ensembl for viewing baseline gene expression and biochemical pathways respectively, but our latest collaboration is with the Protein Data Bank in Europe (PDBe) to show genetic variation on protein structures.
The number of genes and transcripts we have in Ensembl can make your VEP results very big. Filtering your results after running the VEP is the best way to make this more manageable, but you can also reduce the results in your run itself, to only get one result per variant or variant/gene combo.