As Ensembl continues to rapidly grow in terms of the number of supported species, we continually assess our provided resources effectively match the scientific needs of the researchers using them. 

In order to maintain our BioMart service at its current performance level, we will be making changes to data availability in BioMart starting with the upcoming e99 release. 

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Following our consultation on simplifying our GRCh37 services, we have decided to remove all support for non-human data from our dedicated GRCh37 database from release 100 onwards in early 2020. This will impact the website at grch37.ensembl.org, the REST server at rest.grch37.ensembl.org and the database at ensembldb.ensembl.org:3337. Non-human data will still be supported on the e75.ensembl.org archive.

In response to feedback during consultation, access to the full data currently provided by the existing GRCh37 REST services will also be made available for at least a year.

Please see our longer post for more details.

We’re looking for a bioinformatician to join our genebuild team, working on annotating genes onto genomes, particularly as part of the Darwin Tree of Life project. We’re looking for MScs or PhDs in Computer Science, Bioinformatics or Genetics, with experience working with complex code, genomics and alignments. Closes 20th November.

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Some missense variants have significant impact on the protein function, some do not. In the absence of global comprehensive functional assays of missense variants, the next best way to assess if a missense variant is likely to be pathogenic is through prediction tools which take into account factors like the chemical properties of amino acids, functional protein domains and protein conservation to predict how likely it is that a missense variant will impact function. A number of different missense pathogenicity predictors are available for human through Ensembl VEP, and these are are optimised for different purposes.

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