We’re looking for a developer to work on comparative genomics analysis including gene trees, homologues and whole genome alignments. We’re looking for PhDs in molecular biology or bioinformatics with experience in object oriented programming, comparative genomics and high performance computing. Closes 12th June.
Author: Emily (Outreach)
We’re looking for a bioinformatics manager to lead the UK branch of the WormBase consortium within Ensembl for parasitic worm genome data management. We’re looking for PhDs in Molecular Biology or Bioinformatics with experience in model organism genomics, databases and programming. Closes 12th June.
We’re looking for a bioinformatics manager to lead a team working on comparing genes and genomes between species. We’re looking for PhDs Molecular Biology or Bioinformatics with experience in comparative genomics, relational databases, high performance computing and a coding language. Closes 12th June.
If you’re trying to work out which variants are associated with a phenotype or disease, a major thing you might want to know is if someone else has already spotted it. And if not the variant, maybe the gene that it hits. You can get that through the VEP.
The RefSeq column on our gene pages has changed.
We’re moving towards a more unified gene-set with RefSeq, with biologically important transcripts being highlighted as MANE. This means displays you’re used to seeing will be updated to reflect these changes, and this may affect the way you have been working with Ensembl.
We’re fortunate to be part of the EMBL European Bioinformatics Institute (EBI), which puts us alongside stellar bioinformaticians and resources in every discipline. From this, great collaborations can grow. We’ve already worked with our colleagues at Gene Expression Atlas and Reactome to embed widgets in Ensembl for viewing baseline gene expression and biochemical pathways respectively, but our latest collaboration is with the Protein Data Bank in Europe (PDBe) to show genetic variation on protein structures.
The number of genes and transcripts we have in Ensembl can make your VEP results very big. Filtering your results after running the VEP is the best way to make this more manageable, but you can also reduce the results in your run itself, to only get one result per variant or variant/gene combo.
As the community’s capacity for genome sequencing expands, so do its ambitions. Recently, many exciting global genomics projects have been launched, including the Vertebrate Genomes Project (VGP), Darwin Tree of Life (DToL), Earth Biogenome Project EBP, i5K (insects) and 10KP (plants). Between them, they aim to sequence the genomes of every eukaryote on Earth, and Ensembl are excited to take on the annotation of some of those genomes.