As Ensembl continues to rapidly grow in terms of the number of supported species, we continually assess our provided resources effectively match the scientific needs of the researchers using them.
In order to maintain our BioMart service at its current performance level, we will be making changes to data availability in BioMart starting with the upcoming e99 release.
Following our consultation on simplifying our GRCh37 services, we have decided to remove all support for non-human data from our dedicated GRCh37 database from release 100 onwards in early 2020. This will impact the website at grch37.ensembl.org, the REST server at rest.grch37.ensembl.org and the database at ensembldb.ensembl.org:3337. Non-human data will still be supported on the e75.ensembl.org archive.
In response to feedback during consultation, access to the full data currently provided by the existing GRCh37 REST services will also be made available for at least a year.
Please see our longer post for more details.
On the 13th of November between 10:30-11:30 am (GMT) the following Ensembl services will have reduced functionality.
- Ensembl mirrors
By default VEP will tell you the consequences for every transcript affected by a variant. You may wish to prioritise your analysis to only the most important or well supported transcripts for each gene, and VEP provides information to help you do that.
We’re looking for a web development manager to lead our back-end web-team, developing web infrastructure and APIs. We’re looking for MScs or PhDs in biology, bioinformatics, software engineering with experience working with IT infrastructure, containers, data management and Linux. Closes 29th November.
Some missense variants have significant impact on the protein function, some do not. In the absence of global comprehensive functional assays of missense variants, the next best way to assess if a missense variant is likely to be pathogenic is through prediction tools which take into account factors like the chemical properties of amino acids, functional protein domains and protein conservation to predict how likely it is that a missense variant will impact function. A number of different missense pathogenicity predictors are available for human through Ensembl VEP, and these are are optimised for different purposes.
We’re pleased to announce the release of Ensembl 98, and the corresponding Ensembl Genomes release 45. We have a new Post-GWAS Analysis tool and a drove of pig and fish genomes.