Job: Regulation Project Leader

We’re looking for a developer/manager to lead our efforts to annotate the genome with features that regulate gene expression, working with data from large scale epigenomics projects. We’re looking for PhDs in molecular biology, bioinformatics or genomics with experience in gene regulation and high-performance computing. Closes 7th December.

Location: EMBL-EBI, Hinxton near Cambridge, UK
Staff Category: Staff Member
Contract Duration: 3 years
Grading: 7 (monthly salary starting at £3351 after tax)
Closing Date: 7 December 2018
Reference Number: EBI01311

The Ensembl project seeks a dynamic project leader to lead its gene expression regulation efforts.

Ensembl is one of the most successful large-scale bioinformatics projects. We process massive amounts of data from various genomic archives and create new resources for genome analysis. Within the overall project, Ensembl Regulation is specialised in processing large quantities of epigenomic datasets (ChIP-Seq, DNase1 hypersensitivity etc.), which are used to define the Ensembl Regulatory Build, an exhaustive annotation of regulatory elements across the genome and across cell types. This position will give you the chance to determine what datasets and assays will go in Ensembl’s future cis-regulatory annotation, and how they are incorporated or analysed.

Ensembl Regulation is a component of the Genome Analysis team (led by Daniel Zerbino) which is itself part of Ensembl (led by Paul Flicek). EMBL-EBI is a part of the European Molecular Biology Laboratory (EMBL) and is Europe’s leading provider of information services to biological researchers in academia and industry.

Your role

You will be a member of EMBL-EBI’s Genome Analysis team and responsible for the day-to-day management of the Ensembl Regulation project, specifically:

  • Manage and mentor a team of 4-5 developers,
  • Design new features and tools in Ensembl,
  • Engage users to understand their needs,
  • Interact with data providers to gather useful datasets,
  • Define the data processing goals of the team for upcoming Ensembl releases,
  • Participate in Ensembl-wide meetings to coordinate data production and feature development,
  • Manage Ensembl’s contribution to multiple external collaborations such as the International Human Epigenome Consortium (IHEC), the Functional Annotation of Animal Genomes (FAANG) project, MultipleMS and Open Targets,
  • Monitor project advancement to ensure on-time delivery of project results,
  • Represent the team at epigenomics meetings world-wide,
  • Write papers describing results produced by the team,
  • Attend seminars and read papers to keep up-to-date with current research.

You have

We are looking for candidates who:

  • Are knowledgeable in the biology of gene expression regulation,
  • Are knowledgeable in the field of epigenomics and bioinformatics,
  • Have experience working in large, preferably international, consortia,
  • Have experience analysing genomic datasets to answer a research question,
  • Have coding experience.

The ideal candidate will hold a PhD or equivalent in Molecular Biology, Genomics, Bioinformatics or related field with demonstrated experience in genome regulation. Applicants with a MSc and appropriate experience will also be considered.

You will have excellent communication skills to lead with a project where biological and computational scientists work closely together. You will also be highly organised in order to meet the regular deadlines, reports and procedures across the greater Ensembl project.

Although development is not the focus of this position, you must also be familiar with software development practices and high-throughput computing. The ability to understand Perl and MySQL code is required.

You might also have

Past management experience as well as advanced coding skills, in particular proficiency with Perl, MySQL, Git and C will be considered a plus.

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. The remuneration package comprises a competitive salary, a comprehensive pension scheme and health insurance, educational and other family related benefits where applicable, as well as financial support for relocation and installation. For more information about pay and benefits click here.

We have an informal culture, international working environment and excellent professional development opportunities but one of the really amazing things about us is the concentration of technical and scientific expertise – something you probably won’t find anywhere else.

If you’ve ever visited the campus you’ll have experienced first-hand our friendly, collegial and supportive atmosphere, set in the beautiful Cambridgeshire countryside. Our staff also enjoy excellent sports facilities including a gym, a free shuttle bus, an on-site nursery, cafés and restaurant and a library.

What else do I need to know

To view a copy of the job description please click here Applications are welcome from all nationalities – visa information will be discussed in more depth with applicants selected for interview.

EMBL-EBI is committed to achieving gender balance and strongly encourages applications from women, who are currently under-represented at all levels. Appointment will be based on merit alone.

The initial contract is for a period of three years with the possibility of a fixed-term extension.

Applications will close at 23:00 British time on the date listed above.

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